Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Tolmetin
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir and emtricitabine are eliminated by the kidney, and NSAIDs can reduce renal blood flow. Together they may increase tenofovir exposure and the risk of renal injury, especially with high or repeated NSAID doses.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-induced reduction in renal perfusion plus competition for renal tubular elimination increases tenofovir nephrotoxicity risk.
What to do
Prefer alternatives such as paracetamol where possible. If an NSAID is needed, use the lowest dose briefly and monitor serum creatinine and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Tolmetin?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir and emtricitabine are eliminated by the kidney, and NSAIDs can reduce renal blood flow. Together they may increase tenofovir exposure and the risk of renal injury, especially with high or repeated NSAID doses.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer alternatives such as paracetamol where possible. If an NSAID is needed, use the lowest dose briefly and monitor serum creatinine and phosphate.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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