Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Valganciclovir
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Valganciclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganciclovir, emtricitabine and tenofovir are all cleared renally by filtration and tubular secretion. Combining them may increase concentrations of each and add to renal toxicity. Cobicistat can also raise serum creatinine by inhibiting tubular secretion, complicating assessment.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion plus additive nephrotoxicity.
What to do
Monitor serum creatinine, phosphate, urine protein and blood counts, and adjust the valganciclovir dose to creatinine clearance. Stop the combination tablet if estimated creatinine clearance falls below labeled limits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valganciclovir
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Valganciclovir?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganciclovir, emtricitabine and tenofovir are all cleared renally by filtration and tubular secretion. Combining them may increase concentrations of each and add to renal toxicity. Cobicistat can also raise serum creatinine by inhibiting tubular secretion, complicating assessment.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Valganciclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate, urine protein and blood counts, and adjust the valganciclovir dose to creatinine clearance. Stop the combination tablet if estimated creatinine clearance falls below labeled limits.
What other medicines interact with Valganciclovir?
MediHelp also lists interactions of Valganciclovir with, for example, Didanosine, Ganciclovir, Liposomal doxorubicin. The full list is on the Valganciclovir page.
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