Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Vinorelbine
Severity: Major
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Vinorelbine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat may increase vinorelbine exposure by inhibiting CYP3A4. This could worsen neutropenia, neuropathy and constipation.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cobicistat inhibits CYP3A4 and P-glycoprotein, reducing vinorelbine clearance.
What to do
Prefer an unboosted antiretroviral regimen. If combined, check neutrophil counts before each dose and reduce the vinorelbine dose for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinorelbine
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Vinorelbine?
MediHelp rates the interaction as major. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat may increase vinorelbine exposure by inhibiting CYP3A4. This could worsen neutropenia, neuropathy and constipation.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Vinorelbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an unboosted antiretroviral regimen. If combined, check neutrophil counts before each dose and reduce the vinorelbine dose for toxicity.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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