Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine
Severity: Contraindicated
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Zidovudine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This fixed-dose product is a complete HIV regimen and is not intended for use with other antiretrovirals. Adding zidovudine duplicates the nucleoside backbone, adds hematologic toxicity, and offers no proven benefit.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Zidovudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Therapeutic duplication of nucleoside reverse transcriptase inhibitors, with additive toxicity and no established benefit.
What to do
Do not co-administer; use the complete regimen alone or build a different regimen. Discontinue zidovudine if the single-tablet regimen is chosen.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Zidovudine
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
- Clozapine + Zidovudine Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Zidovudine?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Zidovudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This fixed-dose product is a complete HIV regimen and is not intended for use with other antiretrovirals. Adding zidovudine duplicates the nucleoside backbone, adds hematologic toxicity, and offers no proven benefit.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Zidovudine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use the complete regimen alone or build a different regimen. Discontinue zidovudine if the single-tablet regimen is chosen.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Stavudine, Atidarsagene autotemcel, Betibeglogene autotemcel. The full list is on the Zidovudine page.
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