Drug interactions
Atidarsagene autotemcel + Zidovudine
Severity: Major
Atidarsagene autotemcel and Zidovudine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antiretrovirals can interfere with lentiviral vector transduction during manufacture of gene therapy products. Residual drug in collected cells may reduce the efficacy of the product.
What this interaction means in plain words
Atidarsagene autotemcel and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Zidovudine belongs to Anti Virals.
Why it happens
Zidovudine inhibits reverse transcription, impairing lentiviral transduction of harvested cells.
What to do
Stop zidovudine at least one month before mobilization and until apheresis is complete, using an alternative approach if HIV therapy is required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atidarsagene autotemcel and Zidovudine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
- Clozapine + Zidovudine Major
Other interactions of Atidarsagene autotemcel
Frequently asked questions
Can I take Atidarsagene autotemcel with Zidovudine?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretrovirals can interfere with lentiviral vector transduction during manufacture of gene therapy products. Residual drug in collected cells may reduce the efficacy of the product.
How serious is the interaction between Atidarsagene autotemcel and Zidovudine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop zidovudine at least one month before mobilization and until apheresis is complete, using an alternative approach if HIV therapy is required.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Betibeglogene autotemcel. The full list is on the Zidovudine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
