Drug interactions
Emapalumab + Siponimod
Severity: Moderate
Emapalumab and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siponimod lowers circulating lymphocytes, while emapalumab blocks interferon gamma, a key signal for defence against intracellular pathogens. Used together, they may add to the risk of serious infection, including opportunistic and mycobacterial infections.
What this interaction means in plain words
Emapalumab and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Emapalumab belongs to Miscellaneous; Siponimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression through S1P-receptor-mediated lymphocyte sequestration and interferon gamma neutralisation.
What to do
Monitor closely for signs of infection and screen for latent tuberculosis according to emapalumab labeling. Reassess the need for both agents if infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Emapalumab
Frequently asked questions
Can I take Emapalumab with Siponimod?
MediHelp rates the interaction as moderate. Emapalumab and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Siponimod lowers circulating lymphocytes, while emapalumab blocks interferon gamma, a key signal for defence against intracellular pathogens. Used together, they may add to the risk of serious infection, including opportunistic and mycobacterial infections.
How serious is the interaction between Emapalumab and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for signs of infection and screen for latent tuberculosis according to emapalumab labeling. Reassess the need for both agents if infection develops.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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