Drug interactions
Empagliflozin-linagliptin + Istradefylline
Severity: Minor
Empagliflozin-linagliptin and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At the 40 mg daily dose, istradefylline increases exposure to CYP3A4 and P-glycoprotein substrates, which may raise linagliptin levels. Linagliptin has a wide safety margin, so the clinical effect is expected to be small.
What this interaction means in plain words
Empagliflozin-linagliptin and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-linagliptin belongs to Endocrine; Istradefylline belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 and P-glycoprotein by istradefylline at higher doses reduces linagliptin clearance.
What to do
No routine dose change is needed; monitor blood glucose and tolerability if istradefylline 40 mg daily is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Istradefylline
Frequently asked questions
Can I take Empagliflozin-linagliptin with Istradefylline?
MediHelp rates the interaction as minor. Empagliflozin-linagliptin and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At the 40 mg daily dose, istradefylline increases exposure to CYP3A4 and P-glycoprotein substrates, which may raise linagliptin levels. Linagliptin has a wide safety margin, so the clinical effect is expected to be small.
How serious is the interaction between Empagliflozin-linagliptin and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor blood glucose and tolerability if istradefylline 40 mg daily is used.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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