Drug interactions
Empagliflozin-linagliptin + Nateglinide
Severity: Moderate
Empagliflozin-linagliptin and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide stimulates insulin release regardless of glucose-lowering partners, and empagliflozin adds glucose lowering through urinary glucose loss. Together they can increase the likelihood of hypoglycemia, though the risk with empagliflozin alone is low.
What this interaction means in plain words
Empagliflozin-linagliptin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive glucose-lowering pharmacodynamic effects of an insulin secretagogue and an SGLT2 inhibitor.
What to do
Monitor blood glucose when starting or intensifying the combination and consider reducing the nateglinide dose if hypoglycemia occurs. Educate patients on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Empagliflozin-linagliptin with Nateglinide?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nateglinide stimulates insulin release regardless of glucose-lowering partners, and empagliflozin adds glucose lowering through urinary glucose loss. Together they can increase the likelihood of hypoglycemia, though the risk with empagliflozin alone is low.
How serious is the interaction between Empagliflozin-linagliptin and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or intensifying the combination and consider reducing the nateglinide dose if hypoglycemia occurs. Educate patients on hypoglycemia symptoms.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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