Drug interactions
Empagliflozin-linagliptin + Primidone
Severity: Moderate
Empagliflozin-linagliptin and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolised to phenobarbital and acts as an enzyme inducer, so it is expected to lower linagliptin concentrations. This may lead to reduced glycemic control.
What this interaction means in plain words
Empagliflozin-linagliptin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Primidone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 and P-gp by primidone and its phenobarbital metabolite increases linagliptin clearance.
What to do
Monitor glucose control closely and consider an alternative antidiabetic agent if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Empagliflozin-linagliptin with Primidone?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolised to phenobarbital and acts as an enzyme inducer, so it is expected to lower linagliptin concentrations. This may lead to reduced glycemic control.
How serious is the interaction between Empagliflozin-linagliptin and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control closely and consider an alternative antidiabetic agent if the response is inadequate.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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