Drug interactions
Empagliflozin-linagliptin + Somatrogon
Severity: Moderate
Empagliflozin-linagliptin and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatrogon, a long-acting growth hormone, can reduce insulin sensitivity and raise blood glucose. This may offset the glucose-lowering effects of empagliflozin and linagliptin.
What this interaction means in plain words
Empagliflozin-linagliptin and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone induces insulin resistance and increases hepatic glucose output.
What to do
Monitor glucose and HbA1c when somatrogon is started or the dose is changed. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Empagliflozin-linagliptin with Somatrogon?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatrogon, a long-acting growth hormone, can reduce insulin sensitivity and raise blood glucose. This may offset the glucose-lowering effects of empagliflozin and linagliptin.
How serious is the interaction between Empagliflozin-linagliptin and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c when somatrogon is started or the dose is changed. Adjust antidiabetic therapy as needed.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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