Drug interactions
Empagliflozin-linagliptin + Triamterene
Severity: Moderate
Empagliflozin-linagliptin and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin has osmotic diuretic effects and triamterene is a potassium-sparing diuretic, so combined use can increase fluid loss. Volume depletion, hypotension and renal function changes may follow.
What this interaction means in plain words
Empagliflozin-linagliptin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Triamterene belongs to Cardiovascular.
Why it happens
Additive diuretic and natriuretic effects.
What to do
Monitor blood pressure, volume status, renal function and potassium after initiation. Lower the diuretic dose if volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Empagliflozin-linagliptin with Triamterene?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin has osmotic diuretic effects and triamterene is a potassium-sparing diuretic, so combined use can increase fluid loss. Volume depletion, hypotension and renal function changes may follow.
How serious is the interaction between Empagliflozin-linagliptin and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status, renal function and potassium after initiation. Lower the diuretic dose if volume depletion develops.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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