Drug interactions
Empagliflozin-metformin + Enalapril
Severity: Moderate
Empagliflozin-metformin and Enalapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance insulin sensitivity and occasionally cause hypoglycemia. Renal function decline can also reduce metformin clearance and raise lactic acidosis risk, with empagliflozin adding to volume-related kidney risk.
What this interaction means in plain words
Empagliflozin-metformin and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Enalapril belongs to Cardiovascular.
Why it happens
ACE inhibition may improve insulin sensitivity and alter renal hemodynamics, reducing metformin clearance if renal function falls.
What to do
Monitor renal function, volume status and glucose when starting or changing enalapril. Stop metformin if acute kidney injury or eGFR below labeled limits occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Empagliflozin-metformin with Enalapril?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance insulin sensitivity and occasionally cause hypoglycemia. Renal function decline can also reduce metformin clearance and raise lactic acidosis risk, with empagliflozin adding to volume-related kidney risk.
How serious is the interaction between Empagliflozin-metformin and Enalapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, volume status and glucose when starting or changing enalapril. Stop metformin if acute kidney injury or eGFR below labeled limits occurs.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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