Drug interactions
Empagliflozin-metformin + Ethinylestradiol
Severity: Minor
Empagliflozin-metformin and Ethinylestradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinylestradiol-containing contraceptives can slightly worsen glucose tolerance and insulin resistance. Glycemic control in patients taking empagliflozin-metformin may therefore be somewhat reduced, particularly with higher estrogen doses.
What this interaction means in plain words
Empagliflozin-metformin and Ethinylestradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism, as estrogen-progestin products can reduce insulin sensitivity.
What to do
Monitor blood glucose and HbA1c after starting or stopping the contraceptive. Increase the antidiabetic dose only if control deteriorates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Empagliflozin-metformin and Ethinylestradiol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Empagliflozin-metformin
Frequently asked questions
Can I take Empagliflozin-metformin with Ethinylestradiol?
MediHelp rates the interaction as minor. Empagliflozin-metformin and Ethinylestradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinylestradiol-containing contraceptives can slightly worsen glucose tolerance and insulin resistance. Glycemic control in patients taking empagliflozin-metformin may therefore be somewhat reduced, particularly with higher estrogen doses.
How serious is the interaction between Empagliflozin-metformin and Ethinylestradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping the contraceptive. Increase the antidiabetic dose only if control deteriorates.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
