Drug interactions
Empagliflozin-metformin + Fleroxacin
Severity: Moderate
Empagliflozin-metformin and Fleroxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia, especially in older adults and patients on antidiabetic drugs. Glycemic control may become unstable during treatment with fleroxacin.
What this interaction means in plain words
Empagliflozin-metformin and Fleroxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluoroquinolones alter pancreatic beta-cell insulin release, causing dysglycemia that adds to antidiabetic effects.
What to do
Monitor blood glucose closely during and shortly after the antibiotic course and counsel the patient on hypoglycemia symptoms. Consider a non-quinolone antibiotic if dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Frequently asked questions
Can I take Empagliflozin-metformin with Fleroxacin?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Fleroxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia, especially in older adults and patients on antidiabetic drugs. Glycemic control may become unstable during treatment with fleroxacin.
How serious is the interaction between Empagliflozin-metformin and Fleroxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and shortly after the antibiotic course and counsel the patient on hypoglycemia symptoms. Consider a non-quinolone antibiotic if dysglycemia occurs.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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