Drug interactions
Empagliflozin-metformin + Fosphenytoin
Severity: Moderate
Empagliflozin-metformin and Fosphenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin, the active form of fosphenytoin, can inhibit insulin secretion and raise blood glucose. Control may worsen in diabetic patients, and hypoglycemia can occur if phenytoin is later withdrawn.
What this interaction means in plain words
Empagliflozin-metformin and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Fosphenytoin belongs to Central Nervous System.
Why it happens
Phenytoin suppresses pancreatic insulin release, antagonizing the glucose-lowering effect.
What to do
Monitor blood glucose when starting, adjusting or stopping fosphenytoin. Adjust antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Empagliflozin-metformin with Fosphenytoin?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin, the active form of fosphenytoin, can inhibit insulin secretion and raise blood glucose. Control may worsen in diabetic patients, and hypoglycemia can occur if phenytoin is later withdrawn.
How serious is the interaction between Empagliflozin-metformin and Fosphenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, adjusting or stopping fosphenytoin. Adjust antidiabetic doses as needed.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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