Drug interactions
Empagliflozin-metformin + Glibenclamide
Severity: Moderate
Empagliflozin-metformin and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SGLT2 inhibitor with glyburide increases the risk of hypoglycemia. Glyburide's active metabolites can prolong hypoglycemia, especially in renal impairment or in older patients.
What this interaction means in plain words
Empagliflozin-metformin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Glibenclamide belongs to Endocrine.
Why it happens
Additive glucose lowering from insulin secretion stimulation by the sulfonylurea and urinary glucose excretion by empagliflozin.
What to do
Consider reducing the glyburide dose when starting empagliflozin, and monitor blood glucose, particularly in older patients and those with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Empagliflozin-metformin with Glibenclamide?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SGLT2 inhibitor with glyburide increases the risk of hypoglycemia. Glyburide's active metabolites can prolong hypoglycemia, especially in renal impairment or in older patients.
How serious is the interaction between Empagliflozin-metformin and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose when starting empagliflozin, and monitor blood glucose, particularly in older patients and those with renal impairment.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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