Drug interactions
Empagliflozin-metformin + Hydrocortisone
Severity: Moderate
Empagliflozin-metformin and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone can raise blood glucose and reduce the effect of antidiabetic drugs. The impact depends on dose and duration and is greatest with systemic therapy.
What this interaction means in plain words
Empagliflozin-metformin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Hydrocortisone belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and increased hepatic gluconeogenesis oppose the glucose-lowering drugs.
What to do
Monitor blood glucose when starting or changing systemic hydrocortisone. Adjust antidiabetic therapy if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Empagliflozin-metformin with Hydrocortisone?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrocortisone can raise blood glucose and reduce the effect of antidiabetic drugs. The impact depends on dose and duration and is greatest with systemic therapy.
How serious is the interaction between Empagliflozin-metformin and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing systemic hydrocortisone. Adjust antidiabetic therapy if hyperglycemia develops.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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