Drug interactions
Empagliflozin-metformin + Ibuprofen / famotidine
Severity: Moderate
Empagliflozin-metformin and Ibuprofen / famotidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine is renally secreted through cationic transporters and may modestly raise metformin exposure. Ibuprofen can reduce renal function and, together with the SGLT2 inhibitor's effect on volume, may raise the risk of kidney injury and metformin accumulation.
What this interaction means in plain words
Empagliflozin-metformin and Ibuprofen / famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Famotidine may compete with metformin for renal tubular secretion, and NSAID-related reduction in renal perfusion can decrease metformin clearance.
What to do
Monitor renal function and hydration, especially in older patients or with existing kidney impairment. Avoid prolonged NSAID use where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Frequently asked questions
Can I take Empagliflozin-metformin with Ibuprofen / famotidine?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Ibuprofen / famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Famotidine is renally secreted through cationic transporters and may modestly raise metformin exposure. Ibuprofen can reduce renal function and, together with the SGLT2 inhibitor's effect on volume, may raise the risk of kidney injury and metformin accumulation.
How serious is the interaction between Empagliflozin-metformin and Ibuprofen / famotidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and hydration, especially in older patients or with existing kidney impairment. Avoid prolonged NSAID use where possible.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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