Drug interactions
Empagliflozin-metformin + Indapamide
Severity: Moderate
Empagliflozin-metformin and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin adds to the diuretic effect of indapamide, which increases the chance of volume depletion, hypotension and electrolyte disturbances. Renal function decline may also increase metformin exposure.
What this interaction means in plain words
Empagliflozin-metformin and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Indapamide belongs to Cardiovascular.
Why it happens
Additive diuretic and natriuretic effects cause intravascular volume depletion.
What to do
Monitor volume status, blood pressure, electrolytes and renal function after starting. Consider lowering the diuretic dose if signs of volume depletion appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Indapamide
Frequently asked questions
Can I take Empagliflozin-metformin with Indapamide?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin adds to the diuretic effect of indapamide, which increases the chance of volume depletion, hypotension and electrolyte disturbances. Renal function decline may also increase metformin exposure.
How serious is the interaction between Empagliflozin-metformin and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor volume status, blood pressure, electrolytes and renal function after starting. Consider lowering the diuretic dose if signs of volume depletion appear.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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