Drug interactions
Empagliflozin-metformin + Liotrix
Severity: Moderate
Empagliflozin-metformin and Liotrix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone replacement at doses that produce a hyperthyroid state can raise blood glucose and increase glucose requirements in people with diabetes. Glycemic control on empagliflozin-metformin may therefore worsen after liotrix is started or its dose is increased. Glucose may fall again when thyroid hormone is reduced or stopped.
What this interaction means in plain words
Empagliflozin-metformin and Liotrix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thyroid hormones increase hepatic glucose output and glucose absorption and oppose the glucose-lowering effect of antidiabetic drugs (pharmacodynamic antagonism).
What to do
Monitor blood glucose and HbA1c when liotrix is started or its dose changed, and adjust antidiabetic therapy as needed. Keep thyroid replacement at the lowest dose that normalizes TSH.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Frequently asked questions
Can I take Empagliflozin-metformin with Liotrix?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Liotrix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone replacement at doses that produce a hyperthyroid state can raise blood glucose and increase glucose requirements in people with diabetes. Glycemic control on empagliflozin-metformin may therefore worsen after liotrix is started or its dose is increased. Glucose may fall again when thyroid hormone is reduced or stopped.
How serious is the interaction between Empagliflozin-metformin and Liotrix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when liotrix is started or its dose changed, and adjust antidiabetic therapy as needed. Keep thyroid replacement at the lowest dose that normalizes TSH.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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