Drug interactions
Empagliflozin-metformin + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Empagliflozin-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This regimen may raise metformin exposure modestly, and metformin carries a risk of lactic acidosis if levels accumulate, especially with renal or hepatic impairment. Ritonavir may also cause hyperglycemia.
What this interaction means in plain words
Empagliflozin-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal transporters such as MATE1 and OCT2 by components of the regimen may raise metformin concentrations.
What to do
Monitor glycemic control and renal function and watch for signs of lactic acidosis. Avoid in patients with renal or hepatic impairment and reduce metformin dose if exposure is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Frequently asked questions
Can I take Empagliflozin-metformin with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This regimen may raise metformin exposure modestly, and metformin carries a risk of lactic acidosis if levels accumulate, especially with renal or hepatic impairment. Ritonavir may also cause hyperglycemia.
How serious is the interaction between Empagliflozin-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function and watch for signs of lactic acidosis. Avoid in patients with renal or hepatic impairment and reduce metformin dose if exposure is a concern.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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