Drug interactions
Empagliflozin-metformin + Perindopril
Severity: Moderate
Empagliflozin-metformin and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and occasionally cause hypoglycemia. With empagliflozin-related volume loss, falling renal function may raise metformin levels and lactic acidosis risk.
What this interaction means in plain words
Empagliflozin-metformin and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Perindopril belongs to Cardiovascular.
Why it happens
ACE inhibitors may enhance insulin sensitivity and, with volume depletion, reduce renal function and metformin clearance.
What to do
Monitor renal function, volume status, and glucose after starting or adjusting therapy. Hold metformin during acute kidney injury or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Empagliflozin-metformin with Perindopril?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and occasionally cause hypoglycemia. With empagliflozin-related volume loss, falling renal function may raise metformin levels and lactic acidosis risk.
How serious is the interaction between Empagliflozin-metformin and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, volume status, and glucose after starting or adjusting therapy. Hold metformin during acute kidney injury or dehydration.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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