Drug interactions
Empagliflozin-metformin + Quinapril
Severity: Moderate
Empagliflozin-metformin and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and occasionally lead to hypoglycemia in patients on antidiabetic drugs. ACE inhibitors may also worsen renal function or volume status, which can raise the risk of metformin accumulation and, with empagliflozin, volume depletion.
What this interaction means in plain words
Empagliflozin-metformin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition improves insulin sensitivity and its renal and hemodynamic effects can reduce metformin clearance and compound SGLT2-inhibitor volume loss.
What to do
Monitor blood glucose, renal function, potassium and volume status after starting or changing quinapril. Reduce antidiabetic doses if hypoglycemia occurs and hold metformin if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Empagliflozin-metformin and Quinapril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Empagliflozin-metformin
Frequently asked questions
Can I take Empagliflozin-metformin with Quinapril?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and occasionally lead to hypoglycemia in patients on antidiabetic drugs. ACE inhibitors may also worsen renal function or volume status, which can raise the risk of metformin accumulation and, with empagliflozin, volume depletion.
How serious is the interaction between Empagliflozin-metformin and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, renal function, potassium and volume status after starting or changing quinapril. Reduce antidiabetic doses if hypoglycemia occurs and hold metformin if renal function declines.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
