Drug interactions
Empagliflozin-metformin + Tenofovir df
Severity: Moderate
Empagliflozin-metformin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir disoproxil can cause renal tubular injury and reduced kidney function, which may impair metformin elimination. Reduced metformin clearance raises the risk of metformin accumulation and lactic acidosis. Empagliflozin also depends on adequate renal function for glycemic effect.
What this interaction means in plain words
Empagliflozin-metformin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tenofovir-associated nephrotoxicity decreases renal clearance of metformin, which is eliminated unchanged by tubular secretion.
What to do
Monitor serum creatinine and eGFR regularly and reduce or stop metformin if renal function declines. Watch for symptoms of lactic acidosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Empagliflozin-metformin and Tenofovir df, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Empagliflozin-metformin
Frequently asked questions
Can I take Empagliflozin-metformin with Tenofovir df?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir disoproxil can cause renal tubular injury and reduced kidney function, which may impair metformin elimination. Reduced metformin clearance raises the risk of metformin accumulation and lactic acidosis. Empagliflozin also depends on adequate renal function for glycemic effect.
How serious is the interaction between Empagliflozin-metformin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR regularly and reduce or stop metformin if renal function declines. Watch for symptoms of lactic acidosis.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
