Drug interactions
Enalapril + Enoxaparin
Severity: Moderate
Enalapril and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enoxaparin can suppress aldosterone secretion and raise serum potassium. With enalapril, hyperkalemia is more likely, especially in patients with renal impairment or diabetes.
What this interaction means in plain words
Enalapril and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Additive reduction in aldosterone from heparin effect on the adrenal gland and ACE inhibition, causing potassium retention.
What to do
Monitor serum potassium and renal function if enoxaparin continues beyond a few days. Treat hyperkalemia and review potassium-raising drugs if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enalapril with Enoxaparin?
MediHelp rates the interaction as moderate. Enalapril and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enoxaparin can suppress aldosterone secretion and raise serum potassium. With enalapril, hyperkalemia is more likely, especially in patients with renal impairment or diabetes.
How serious is the interaction between Enalapril and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function if enoxaparin continues beyond a few days. Treat hyperkalemia and review potassium-raising drugs if levels rise.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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