Drug interactions
Enalapril + Glipizide-metformin
Severity: Moderate
Enalapril and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and increase hypoglycemia risk with antidiabetic drugs, especially early in treatment. Renal function changes with ACE inhibitors may also increase metformin accumulation.
What this interaction means in plain words
Enalapril and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Glipizide-metformin belongs to Endocrine.
Why it happens
ACE inhibition enhances insulin sensitivity and may affect renal function, altering metformin clearance.
What to do
Monitor blood glucose and renal function after starting enalapril, and adjust glipizide if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Glipizide-metformin?
MediHelp rates the interaction as moderate. Enalapril and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and increase hypoglycemia risk with antidiabetic drugs, especially early in treatment. Renal function changes with ACE inhibitors may also increase metformin accumulation.
How serious is the interaction between Enalapril and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function after starting enalapril, and adjust glipizide if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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