Drug interactions
Enalapril + Glyburide-metformin
Severity: Moderate
Enalapril and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and have been linked to hypoglycemia in patients taking sulfonylureas or insulin. Enalapril may also reduce renal function in susceptible patients, which could favor metformin accumulation.
What this interaction means in plain words
Enalapril and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
ACE inhibition may enhance insulin sensitivity and can reduce renal perfusion, lowering metformin clearance.
What to do
Monitor blood glucose, especially after starting enalapril, and check renal function periodically; reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Glyburide-metformin?
MediHelp rates the interaction as moderate. Enalapril and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and have been linked to hypoglycemia in patients taking sulfonylureas or insulin. Enalapril may also reduce renal function in susceptible patients, which could favor metformin accumulation.
How serious is the interaction between Enalapril and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, especially after starting enalapril, and check renal function periodically; reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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