Drug interactions
Enalapril + Insulin degludec-liraglutide
Severity: Moderate
Enalapril and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors such as enalapril may improve insulin sensitivity and enhance the glucose-lowering effect of insulin and liraglutide. Hypoglycemia can occur, most often in the early weeks of ACE inhibitor therapy.
What this interaction means in plain words
Enalapril and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
ACE inhibition improves insulin sensitivity, adding to the glucose-lowering effect of the antidiabetic drugs.
What to do
Monitor blood glucose closely when enalapril is started and reduce the insulin dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Enalapril and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors such as enalapril may improve insulin sensitivity and enhance the glucose-lowering effect of insulin and liraglutide. Hypoglycemia can occur, most often in the early weeks of ACE inhibitor therapy.
How serious is the interaction between Enalapril and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when enalapril is started and reduce the insulin dose if hypoglycemia develops.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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