Drug interactions
Enalapril + Insulin degludec
Severity: Moderate
Enalapril and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may increase insulin sensitivity and strengthen the glucose-lowering effect of basal insulin. Hypoglycemia may occur more often, especially in the first weeks after the ACE inhibitor is started.
What this interaction means in plain words
Enalapril and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
ACE inhibition increases bradykinin and improves peripheral insulin sensitivity, producing an additive glucose-lowering effect.
What to do
Monitor blood glucose closely when starting or adjusting enalapril. Reduce the insulin degludec dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Enalapril with Insulin degludec?
MediHelp rates the interaction as moderate. Enalapril and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may increase insulin sensitivity and strengthen the glucose-lowering effect of basal insulin. Hypoglycemia may occur more often, especially in the first weeks after the ACE inhibitor is started.
How serious is the interaction between Enalapril and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or adjusting enalapril. Reduce the insulin degludec dose if hypoglycemia develops.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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