Drug interactions
Enalapril + Lofexidine
Severity: Moderate
Enalapril and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine is a central alpha-2 agonist that lowers blood pressure and heart rate. Taken with an ACE inhibitor, it can add to hypotension, and bradycardia and syncope are a concern with lofexidine itself.
What this interaction means in plain words
Enalapril and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic blood pressure lowering from central sympatholytic action and ACE inhibition.
What to do
Monitor blood pressure and pulse during lofexidine initiation and dose changes, and reduce the antihypertensive dose if symptomatic hypotension occurs. Counsel the patient about orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Enalapril with Lofexidine?
MediHelp rates the interaction as moderate. Enalapril and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine is a central alpha-2 agonist that lowers blood pressure and heart rate. Taken with an ACE inhibitor, it can add to hypotension, and bradycardia and syncope are a concern with lofexidine itself.
How serious is the interaction between Enalapril and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse during lofexidine initiation and dose changes, and reduce the antihypertensive dose if symptomatic hypotension occurs. Counsel the patient about orthostatic symptoms.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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