Drug interactions
Enalapril + Metformin-repaglinide
Severity: Moderate
Enalapril and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may lower blood glucose in patients on antidiabetic drugs, occasionally causing hypoglycemia. Any ACE inhibitor-related fall in renal function could also reduce metformin clearance and raise the risk of lactic acidosis.
What this interaction means in plain words
Enalapril and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
Why it happens
Additive glucose-lowering via improved insulin sensitivity, plus possible reduction in renal metformin elimination if renal function declines.
What to do
Monitor blood glucose after starting or changing the ACE inhibitor dose. Check renal function periodically and review metformin dosing if eGFR falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Enalapril and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and may lower blood glucose in patients on antidiabetic drugs, occasionally causing hypoglycemia. Any ACE inhibitor-related fall in renal function could also reduce metformin clearance and raise the risk of lactic acidosis.
How serious is the interaction between Enalapril and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing the ACE inhibitor dose. Check renal function periodically and review metformin dosing if eGFR falls.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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