Drug interactions
Enalapril + Terazosin
Severity: Moderate
Enalapril and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining terazosin with enalapril can produce additive blood pressure reduction and an exaggerated response to the first doses. Symptomatic hypotension and falls are the main concerns.
What this interaction means in plain words
Enalapril and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Terazosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic effect of alpha-1 blockade and ACE inhibition.
What to do
Initiate at low doses, give the first dose at bedtime, and monitor standing and sitting blood pressure. Correct volume depletion before starting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Terazosin?
MediHelp rates the interaction as moderate. Enalapril and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining terazosin with enalapril can produce additive blood pressure reduction and an exaggerated response to the first doses. Symptomatic hypotension and falls are the main concerns.
How serious is the interaction between Enalapril and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Initiate at low doses, give the first dose at bedtime, and monitor standing and sitting blood pressure. Correct volume depletion before starting.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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