Drug interactions
Encorafenib + Eribulin
Severity: Moderate
Encorafenib and Eribulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib causes dose-dependent QT prolongation, and eribulin can also prolong the QT interval. Giving them together may increase the risk of arrhythmia.
What this interaction means in plain words
Encorafenib and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Eribulin belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check a baseline ECG and electrolytes, then monitor periodically. Interrupt or reduce encorafenib per labeling if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Encorafenib and Eribulin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eribulin
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Eribulin?
MediHelp rates the interaction as moderate. Encorafenib and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib causes dose-dependent QT prolongation, and eribulin can also prolong the QT interval. Giving them together may increase the risk of arrhythmia.
How serious is the interaction between Encorafenib and Eribulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, then monitor periodically. Interrupt or reduce encorafenib per labeling if the QTc becomes markedly prolonged.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
