Drug interactions
Encorafenib + Erythromycin
Severity: Major
Encorafenib and Erythromycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin raises encorafenib concentrations through CYP3A4 inhibition, increasing toxicity. Both drugs can also prolong the QT interval, compounding the risk of arrhythmia.
What this interaction means in plain words
Encorafenib and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Encorafenib belongs to Oncology; Erythromycin belongs to Anti Bacterial.
Why it happens
CYP3A4 inhibition increases encorafenib exposure, together with additive QT prolongation.
What to do
Avoid if possible. If unavoidable, reduce encorafenib to half the dose, monitor the ECG and electrolytes, and resume the prior dose after the inhibitor is stopped for 3-5 half-lives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Erythromycin?
MediHelp rates the interaction as major. Encorafenib and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin raises encorafenib concentrations through CYP3A4 inhibition, increasing toxicity. Both drugs can also prolong the QT interval, compounding the risk of arrhythmia.
How serious is the interaction between Encorafenib and Erythromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce encorafenib to half the dose, monitor the ECG and electrolytes, and resume the prior dose after the inhibitor is stopped for 3-5 half-lives.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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