Drug interactions
Encorafenib + Fluticasone-salmeterol
Severity: Moderate
Encorafenib and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib has mixed CYP3A4 effects and can alter exposure to the CYP3A4 substrates salmeterol and fluticasone unpredictably. Both encorafenib and salmeterol can prolong the QT interval, so the combination may add to proarrhythmic risk.
What this interaction means in plain words
Encorafenib and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib plus additive QT prolongation.
What to do
Monitor ECG and electrolytes, and watch for loss of asthma control or beta-agonist adverse effects. Correct potassium and magnesium before starting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Encorafenib and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib has mixed CYP3A4 effects and can alter exposure to the CYP3A4 substrates salmeterol and fluticasone unpredictably. Both encorafenib and salmeterol can prolong the QT interval, so the combination may add to proarrhythmic risk.
How serious is the interaction between Encorafenib and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for loss of asthma control or beta-agonist adverse effects. Correct potassium and magnesium before starting.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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