Drug interactions
Encorafenib + Fluvastatin
Severity: Moderate
Encorafenib and Fluvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib inhibits several drug transporters that handle statins, so fluvastatin exposure could increase. This may heighten the risk of muscle-related adverse effects.
What this interaction means in plain words
Encorafenib and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Fluvastatin belongs to Cardiovascular.
Why it happens
Encorafenib inhibits OATP1B1, OATP1B3 and BCRP, reducing fluvastatin uptake and efflux.
What to do
Monitor for myopathy symptoms and consider lowering the fluvastatin dose while encorafenib is given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Fluvastatin?
MediHelp rates the interaction as moderate. Encorafenib and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib inhibits several drug transporters that handle statins, so fluvastatin exposure could increase. This may heighten the risk of muscle-related adverse effects.
How serious is the interaction between Encorafenib and Fluvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myopathy symptoms and consider lowering the fluvastatin dose while encorafenib is given.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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