Drug interactions
Encorafenib + Foscarnet
Severity: Major
Encorafenib and Foscarnet: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib can prolong the QT interval in a dose-dependent manner, and foscarnet has a similar liability. Using them together may increase the risk of torsade de pointes, especially when electrolyte abnormalities from foscarnet occur.
What this interaction means in plain words
Encorafenib and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Encorafenib belongs to Oncology; Foscarnet belongs to Anti Virals.
Why it happens
Additive QT prolongation, aggravated by foscarnet-induced electrolyte abnormalities.
What to do
Avoid the combination if possible. If it cannot be avoided, monitor ECG and electrolytes regularly and correct abnormalities, reducing or interrupting encorafenib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Foscarnet?
MediHelp rates the interaction as major. Encorafenib and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Encorafenib can prolong the QT interval in a dose-dependent manner, and foscarnet has a similar liability. Using them together may increase the risk of torsade de pointes, especially when electrolyte abnormalities from foscarnet occur.
How serious is the interaction between Encorafenib and Foscarnet?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it cannot be avoided, monitor ECG and electrolytes regularly and correct abnormalities, reducing or interrupting encorafenib if QTc becomes markedly prolonged.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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