Drug interactions
Encorafenib + Hydrochlorothiazide-telmisartan
Severity: Minor
Encorafenib and Hydrochlorothiazide-telmisartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib may inhibit OATP1B3 and could raise telmisartan exposure. The clinical significance has not been established.
What this interaction means in plain words
Encorafenib and Hydrochlorothiazide-telmisartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Encorafenib belongs to Oncology; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Possible inhibition of OATP1B3-mediated hepatic uptake of telmisartan.
What to do
Monitor blood pressure and for telmisartan adverse effects such as hypotension, and adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as minor. Encorafenib and Hydrochlorothiazide-telmisartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Encorafenib may inhibit OATP1B3 and could raise telmisartan exposure. The clinical significance has not been established.
How serious is the interaction between Encorafenib and Hydrochlorothiazide-telmisartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for telmisartan adverse effects such as hypotension, and adjust the dose if needed.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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