Drug interactions
Encorafenib + Imipramine
Severity: Major
Encorafenib and Imipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib can prolong the QT interval in a dose-related way, and imipramine adds to this effect. The risk of torsades de pointes is therefore increased, particularly with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Encorafenib and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Encorafenib belongs to Oncology; Imipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Avoid the combination if possible. Otherwise monitor ECG and electrolytes, and reduce or withhold encorafenib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Imipramine?
MediHelp rates the interaction as major. Encorafenib and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Encorafenib can prolong the QT interval in a dose-related way, and imipramine adds to this effect. The risk of torsades de pointes is therefore increased, particularly with electrolyte disturbance or cardiac disease.
How serious is the interaction between Encorafenib and Imipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. Otherwise monitor ECG and electrolytes, and reduce or withhold encorafenib if QTc becomes markedly prolonged.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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