Drug interactions
Encorafenib + Isosorbide dinitrate
Severity: Minor
Encorafenib and Isosorbide dinitrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so effects on CYP3A4 substrates are unpredictable. Isosorbide dinitrate relies little on CYP3A4, so a significant change in its effect is unlikely.
What this interaction means in plain words
Encorafenib and Isosorbide dinitrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Encorafenib belongs to Oncology; Isosorbide dinitrate belongs to Cardiovascular.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib on a minor nitrate pathway.
What to do
No empirical dose change. Monitor blood pressure and anginal control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Encorafenib and Isosorbide dinitrate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Isosorbide dinitrate?
MediHelp rates the interaction as minor. Encorafenib and Isosorbide dinitrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Encorafenib both inhibits and induces CYP3A4, so effects on CYP3A4 substrates are unpredictable. Isosorbide dinitrate relies little on CYP3A4, so a significant change in its effect is unlikely.
How serious is the interaction between Encorafenib and Isosorbide dinitrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change. Monitor blood pressure and anginal control.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
