Drug interactions
Encorafenib + Ledipasvir-sofosbuvir
Severity: Minor
Encorafenib and Ledipasvir-sofosbuvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib may inhibit intestinal BCRP, and both ledipasvir and sofosbuvir are BCRP substrates. Exposure to the antiviral combination could rise, although the clinical consequence is probably small given its wide safety margin.
What this interaction means in plain words
Encorafenib and Ledipasvir-sofosbuvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Encorafenib belongs to Oncology; Ledipasvir-sofosbuvir belongs to Anti Virals.
Why it happens
Inhibition of BCRP efflux transport by encorafenib may increase absorption of ledipasvir and sofosbuvir.
What to do
No empiric dose change is needed; monitor for adverse effects of the antiviral regimen such as fatigue and headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Ledipasvir-sofosbuvir?
MediHelp rates the interaction as minor. Encorafenib and Ledipasvir-sofosbuvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Encorafenib may inhibit intestinal BCRP, and both ledipasvir and sofosbuvir are BCRP substrates. Exposure to the antiviral combination could rise, although the clinical consequence is probably small given its wide safety margin.
How serious is the interaction between Encorafenib and Ledipasvir-sofosbuvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; monitor for adverse effects of the antiviral regimen such as fatigue and headache.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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