Drug interactions
Encorafenib + Levonorgestrel
Severity: Major
Encorafenib and Levonorgestrel: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib induces CYP3A4 and may lower systemic levonorgestrel concentrations. Contraceptive efficacy of systemic forms may fall, and encorafenib can harm the fetus.
What this interaction means in plain words
Encorafenib and Levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Encorafenib belongs to Oncology; Levonorgestrel belongs to Endocrine.
Why it happens
Encorafenib induces CYP3A4, increasing levonorgestrel metabolism.
What to do
Use a highly effective nonhormonal method during treatment and for 2 weeks after the last dose. Do not rely on oral levonorgestrel contraception.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Levonorgestrel
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Levonorgestrel?
MediHelp rates the interaction as major. Encorafenib and Levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Encorafenib induces CYP3A4 and may lower systemic levonorgestrel concentrations. Contraceptive efficacy of systemic forms may fall, and encorafenib can harm the fetus.
How serious is the interaction between Encorafenib and Levonorgestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a highly effective nonhormonal method during treatment and for 2 weeks after the last dose. Do not rely on oral levonorgestrel contraception.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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