Drug interactions
Encorafenib + Salmeterol
Severity: Moderate
Encorafenib and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib can alter CYP3A4 activity and may change salmeterol exposure, with net inhibition or induction uncertain. Both drugs can also prolong the QT interval, so higher salmeterol levels could increase cardiac effects.
What this interaction means in plain words
Encorafenib and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Salmeterol belongs to Respiratory.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib affecting salmeterol metabolism, plus additive QT prolongation.
What to do
Monitor for tachycardia, tremor and palpitations, and obtain ECG and electrolytes in patients with QT risk factors. Adjust therapy if salmeterol effect appears excessive or reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Salmeterol?
MediHelp rates the interaction as moderate. Encorafenib and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib can alter CYP3A4 activity and may change salmeterol exposure, with net inhibition or induction uncertain. Both drugs can also prolong the QT interval, so higher salmeterol levels could increase cardiac effects.
How serious is the interaction between Encorafenib and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tachycardia, tremor and palpitations, and obtain ECG and electrolytes in patients with QT risk factors. Adjust therapy if salmeterol effect appears excessive or reduced.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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