Drug interactions
Encorafenib + Tadalafil
Severity: Moderate
Encorafenib and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so tadalafil exposure may rise or fall unpredictably. This may cause either toxicity or reduced efficacy.
What this interaction means in plain words
Encorafenib and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Tadalafil belongs to Genitourinary.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib alters tadalafil metabolism.
What to do
Monitor response and adverse effects of tadalafil and adjust the dose accordingly. Consider an alternative if tadalafil is used for pulmonary hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Tadalafil?
MediHelp rates the interaction as moderate. Encorafenib and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so tadalafil exposure may rise or fall unpredictably. This may cause either toxicity or reduced efficacy.
How serious is the interaction between Encorafenib and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response and adverse effects of tadalafil and adjust the dose accordingly. Consider an alternative if tadalafil is used for pulmonary hypertension.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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