Drug interactions
Encorafenib + Tolvaptan
Severity: Moderate
Encorafenib and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so tolvaptan exposure may rise or fall unpredictably. This may lead to excessive aquaresis or loss of sodium-correcting effect.
What this interaction means in plain words
Encorafenib and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Tolvaptan belongs to Endocrine.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib alters tolvaptan metabolism, a sensitive CYP3A4 substrate.
What to do
Monitor serum sodium and clinical response closely after starting or stopping encorafenib. Titrate tolvaptan as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Tolvaptan?
MediHelp rates the interaction as moderate. Encorafenib and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so tolvaptan exposure may rise or fall unpredictably. This may lead to excessive aquaresis or loss of sodium-correcting effect.
How serious is the interaction between Encorafenib and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and clinical response closely after starting or stopping encorafenib. Titrate tolvaptan as needed.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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