Drug interactions
Encorafenib + Valsartan
Severity: Moderate
Encorafenib and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib inhibits hepatic uptake transporters, and valsartan is an OATP1B1/OATP1B3 substrate, so valsartan exposure may rise. This could increase its blood pressure lowering effect and adverse effects such as hyperkalemia or renal changes.
What this interaction means in plain words
Encorafenib and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Valsartan belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1 and OATP1B3 hepatic uptake by encorafenib, reducing hepatic clearance of valsartan.
What to do
Monitor blood pressure, renal function and potassium, and reduce the valsartan dose if signs of excess exposure appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Valsartan?
MediHelp rates the interaction as moderate. Encorafenib and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib inhibits hepatic uptake transporters, and valsartan is an OATP1B1/OATP1B3 substrate, so valsartan exposure may rise. This could increase its blood pressure lowering effect and adverse effects such as hyperkalemia or renal changes.
How serious is the interaction between Encorafenib and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium, and reduce the valsartan dose if signs of excess exposure appear.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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