Drug interactions
Enoxaparin + Factor x human
Severity: Moderate
Enoxaparin and Factor x human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enoxaparin potentiates antithrombin-mediated inhibition of factor Xa, which can neutralize the activity of infused human factor X. This may reduce the hemostatic benefit of factor X replacement in patients with hereditary factor X deficiency.
What this interaction means in plain words
Enoxaparin and Factor x human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: indirect factor Xa inhibition opposes the procoagulant effect of replaced factor X.
What to do
Avoid giving enoxaparin during treatment of bleeding episodes or perioperative prophylaxis with factor X unless thrombosis risk clearly requires it. Monitor factor X activity and clinical hemostasis if both are needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enoxaparin with Factor x human?
MediHelp rates the interaction as moderate. Enoxaparin and Factor x human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enoxaparin potentiates antithrombin-mediated inhibition of factor Xa, which can neutralize the activity of infused human factor X. This may reduce the hemostatic benefit of factor X replacement in patients with hereditary factor X deficiency.
How serious is the interaction between Enoxaparin and Factor x human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving enoxaparin during treatment of bleeding episodes or perioperative prophylaxis with factor X unless thrombosis risk clearly requires it. Monitor factor X activity and clinical hemostasis if both are needed.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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