Drug interactions
Enoxaparin + Hydrocortisone
Severity: Moderate
Enoxaparin and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids may raise bleeding risk through gastrointestinal mucosal and vascular effects when used with low molecular weight heparin. The legacy comment about INR does not apply to enoxaparin.
What this interaction means in plain words
Enoxaparin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enoxaparin belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Additive bleeding risk from steroid mucosal and vascular effects with anticoagulation.
What to do
Monitor for bleeding and hemoglobin, and consider gastroprotection with prolonged steroid use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enoxaparin with Hydrocortisone?
MediHelp rates the interaction as moderate. Enoxaparin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids may raise bleeding risk through gastrointestinal mucosal and vascular effects when used with low molecular weight heparin. The legacy comment about INR does not apply to enoxaparin.
How serious is the interaction between Enoxaparin and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and hemoglobin, and consider gastroprotection with prolonged steroid use.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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