Drug interactions
Enoxaparin + Meclofenamate
Severity: Moderate
Enoxaparin and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate is an NSAID that impairs platelet aggregation and irritates the gastrointestinal tract. With enoxaparin, the risk of bleeding is increased.
What this interaction means in plain words
Enoxaparin and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment from NSAID platelet inhibition plus enoxaparin anticoagulation.
What to do
Avoid if possible, or use the lowest dose for the shortest period with monitoring for bleeding. Consider gastroprotection or paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enoxaparin with Meclofenamate?
MediHelp rates the interaction as moderate. Enoxaparin and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate is an NSAID that impairs platelet aggregation and irritates the gastrointestinal tract. With enoxaparin, the risk of bleeding is increased.
How serious is the interaction between Enoxaparin and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or use the lowest dose for the shortest period with monitoring for bleeding. Consider gastroprotection or paracetamol.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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