Drug interactions
Enoxaparin + Mestranol
Severity: Major
Enoxaparin and Mestranol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mestranol, a prodrug of ethinylestradiol, increases thrombotic risk and can counter enoxaparin therapy. Avoid it in patients treated for thrombosis.
What this interaction means in plain words
Enoxaparin and Mestranol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Estrogenic prothrombotic effects oppose anticoagulation.
What to do
Stop mestranol during acute thromboembolism and switch to non-estrogen contraception.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enoxaparin with Mestranol?
MediHelp rates the interaction as major. Enoxaparin and Mestranol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mestranol, a prodrug of ethinylestradiol, increases thrombotic risk and can counter enoxaparin therapy. Avoid it in patients treated for thrombosis.
How serious is the interaction between Enoxaparin and Mestranol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop mestranol during acute thromboembolism and switch to non-estrogen contraception.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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